According to y. Taanit 1:1, 64a: “In the scroll of R. Meir they found written, instead of 'The burden of Dumah' (Isa. 21:11), 'The burden of Roma [Rome]'.”For those who have ears to hear, let him hear. I should also note that as I was going through Isaiah 21 I couldn't help but think I had heard these words somewhere before. Sure enough, I looked up a biography of Bob Dylan and found it was the inspiration for ...
To begin to understand the theological implications of this passage here is a useful passage from the Jerusalem Talmud. Will transcribe it here shortly.